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Literature summary extracted from

  • Stoll, G.; Kleinschnitz, C.; Nieswandt, B.
    Molecular mechanisms of thrombus formation in ischemic stroke: novel insights and targets for treatment (2008), Blood, 112, 3555-3562.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.38 additional information extracellular RNA, but not DNA, augments (auto)activation of FXII and thereby acts as a potent trigger of coagulation in vivo Mus musculus
3.4.21.38 additional information extracellular RNA, but not DNA, augments (auto)activation of FXII and thereby acts as a potent trigger of coagulation in vivo Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.38 D-Pro-Phe-Arg-chloromethyl ketone
-
 Homo sapiens
3.4.21.38 D-Pro-Phe-Arg-chloromethyl ketone
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.38 additional information Mus musculus FXII plays a functional role in thrombus formation and stabilization during stroke, FXII is an essential component of pathologic thrombus formation but not of physiologic hemostasis ?
-
 ?
3.4.21.38 additional information Homo sapiens FXII plays a functional role in thrombus formation and stabilization during stroke, FXII is an essential component of pathologic thrombus formation but not of physiologic hemostasis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.38 Homo sapiens
-
-
-
3.4.21.38 Mus musculus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.38 factor XI + H2O
-
 Mus musculus factor XIa + ?
-
 ?
3.4.21.38 factor XI + H2O
-
 Homo sapiens factor XIa + ?
-
 ?
3.4.21.38 additional information FXII plays a functional role in thrombus formation and stabilization during stroke, FXII is an essential component of pathologic thrombus formation but not of physiologic hemostasis Mus musculus ?
-
 ?
3.4.21.38 additional information FXII plays a functional role in thrombus formation and stabilization during stroke, FXII is an essential component of pathologic thrombus formation but not of physiologic hemostasis Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.38 FXII
-
 Mus musculus
3.4.21.38 FXII
-
 Homo sapiens
3.4.21.38 Hageman factor
-
 Mus musculus
3.4.21.38 Hageman factor
-
 Homo sapiens